Symbol: Name: ID: |
TRIB3 tribbles homolog 3 (Drosophila) GFS:5356 |
Gene name: | TRIB3 |
Chromosome: | 20p13-p12.2 |
Previous Symbols: | C20orf97 |
Previous Names: | chromosome 20 open reading frame 97 |
Aliases: | dJ1103G7.3, TRB3 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1345675 | Rat Genome Database ID: | RGD:708432 |
HGNC ID: | HGNC:16228 | RefSeq IDs: | NM_021158 |
Entrez Gene ID: | 57761 | Ensembl Gene ID: | ENSG00000101255 |
VEGA IDs: | OTTHUMG00000031627 | UniProt ID: | Q96RU7 |
UCSC ID: | uc002wdm.2 | OMIM ID: | 607898 |
Pubmed: | PMID12791994 PMID 16715410 | ||
CCDS IDs: | CCDSCCDS12997.1 |
Tribbles homolog 3 is a protein that in humans is encoded by the TRIB3 gene.
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity.
Products for TRIB3 gene
Catalog | Product Name | Application | Company |
GFS:E05356 | tribbles homolog 3 (Drosophila); ELISA kit | ELISA | n/a |
GFS:A05356 | tribbles homolog 3 (Drosophila); Anti | ANTIBODIES | n/a |
GFS:P05356 | tribbles homolog 3 (Drosophila); Protien | Protien | n/a |