Symbol: Name: ID: |
TGFA transforming growth factor, alpha GFS:1583 |
Gene name: | TGFA |
Chromosome: | 2p13 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98724 | Rat Genome Database ID: | RGD:3849 |
HGNC ID: | HGNC:11765 | RefSeq IDs: | NM_001099691 |
Entrez Gene ID: | 7039 | Ensembl Gene ID: | ENSG00000163235 |
VEGA IDs: | OTTHUMG00000129669 | UniProt ID: | P01135 |
UCSC ID: | uc002sgs.3 | OMIM ID: | 190170 |
Pubmed: | PMID3459638 PMID 10552925 | ||
CCDS IDs: | CCDSCCDS1905.1 CCDS CCDS46316.1 |
Transforming growth factor alpha (TGF-α) is upregulated in some human cancers. It is produced in macrophages, brain cells, and keratinocytes, and induces epithelial development. It is closely related to EGF, and can also bind to the EGF receptor with similar effects . TGFα stimulates neural cell proliferation in the adult injured brain.
TGFα was cited in the 2001 NIH Stem Cell report to the U.S. Congress as promising evidence for the ability of adult stem cells to restore function in neurodegenerative disorders.
Transforming growth factors (TGFs) are biologically active polypeptides that reversibly confer the transformed phenotype on cultured cells. TGF-alpha shows about 40% sequence homology with epidermal growth factor (EGF; MIM 131530) and competes with EGF for binding to the EGF receptor (MIM 131550), stimulating its phosphorylation and producing a mitogenic response.[supplied by OMIM].
TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
Products for TGFA gene
Catalog | Product Name | Application | Company |
GFS:E01583 | transforming growth factor, alpha; ELISA kit | ELISA | n/a |
GFS:A01583 | transforming growth factor, alpha; Anti | ANTIBODIES | n/a |
GFS:P01583 | transforming growth factor, alpha; Protien | Protien | n/a |