Symbol: Name: ID: |
TRRAP transformation/transcription domain-associated protein GFS:2159 |
Gene name: | TRRAP |
Chromosome: | 7q21.2-q22.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | TR-AP, PAF400, Tra1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2153272 | Rat Genome Database ID: | RGD:1305446 |
HGNC ID: | HGNC:12347 | RefSeq IDs: | NM_003496 |
Entrez Gene ID: | 8295 | Ensembl Gene ID: | ENSG00000196367 |
VEGA IDs: | OTTHUMG00000150403 | UniProt ID: | Q9Y4A5 |
UCSC ID: | uc011kis.1 | OMIM ID: | 603015 |
Pubmed: | PMID9708738 PMID 9885574 | ||
CCDS IDs: | CCDSCCDS5659.1 |
Transformation/transcription domain-associated protein, also known asTRRAP, is a protein which in humans is encoded by the TRRAP gene. Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression.
Products for TRRAP gene
Catalog | Product Name | Application | Company |
GFS:E02159 | transformation/transcription domain-associated protein; ELISA kit | ELISA | n/a |
GFS:A02159 | transformation/transcription domain-associated protein; Anti | ANTIBODIES | n/a |
GFS:P02159 | transformation/transcription domain-associated protein; Protien | Protien | n/a |