Symbol: Name: ID: |
TFRC transferrin receptor (p90, CD71) GFS:1581 |
Gene name: | TFRC |
Chromosome: | 3q26.2-qter |
Previous Symbols: | |
Previous Names: | |
Aliases: | CD71, TFR1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98822 | Rat Genome Database ID: | RGD:70488 |
HGNC ID: | HGNC:11763 | RefSeq IDs: | NM_001128148 |
Entrez Gene ID: | 7037 | Ensembl Gene ID: | ENSG00000072274 |
VEGA IDs: | OTTHUMG00000155714 | UniProt ID: | P02786 |
UCSC ID: | uc003fwa.3 | OMIM ID: | 190010 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS3312.1 |
Transferrin receptor protein 1 (TfR1) also known as (Cluster of Differentiation 71) (CD71) is a protein that in humans is encoded by the TFRC gene. TfR1 is required for iron delivery from transferrin to cells. Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
Products for TFRC gene
Catalog | Product Name | Application | Company |
GFS:E01581 | transferrin receptor (p90, CD71); ELISA kit | ELISA | n/a |
GFS:A01581 | transferrin receptor (p90, CD71); Anti | ANTIBODIES | n/a |
GFS:P01581 | transferrin receptor (p90, CD71); Protien | Protien | n/a |