Symbol: Name: ID: |
TFEB transcription factor EB GFS:1570 |
Gene name: | TFEB |
Chromosome: | 6p21 |
Previous Symbols: | |
Previous Names: | |
Aliases: | TCFEB, bHLHe35 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:103270 | Rat Genome Database ID: | RGD:1309583 |
HGNC ID: | HGNC:11753 | RefSeq IDs: | NM_001167827 |
Entrez Gene ID: | 7942 | Ensembl Gene ID: | ENSG00000112561 |
VEGA IDs: | OTTHUMG00000014684 | UniProt ID: | P19484 |
UCSC ID: | uc003oqs.1 | OMIM ID: | 600744 |
Pubmed: | PMID2115126 | ||
CCDS IDs: | CCDSCCDS4858.1 |
Transcription factor EB is a protein that in humans is encoded by the TFEB gene. Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.
Products for TFEB gene
Catalog | Product Name | Application | Company |
GFS:E01570 | transcription factor EB; ELISA kit | ELISA | n/a |
GFS:A01570 | transcription factor EB; Anti | ANTIBODIES | n/a |
GFS:P01570 | transcription factor EB; Protien | Protien | n/a |