Symbol: Name: ID: |
TFCP2 transcription factor CP2 GFS:1565 |
Gene name: | TFCP2 |
Chromosome: | 12q13 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CP2, LSF, LBP-1C, TFCP2C |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98509 | Rat Genome Database ID: | |
HGNC ID: | HGNC:11748 | RefSeq IDs: | NM_001173452 |
Entrez Gene ID: | 7024 | Ensembl Gene ID: | ENSG00000135457 |
VEGA IDs: | UniProt ID: | Q12800 | |
UCSC ID: | uc001rxw.2 | OMIM ID: | 189889 |
Pubmed: | PMID8157699 | ||
CCDS IDs: | CCDSCCDS8808.1 |
Alpha-globin transcription factor CP2 is a protein that in humans is encoded by the TFCP2 gene. This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease. [provided by RefSeq].
Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter.
Products for TFCP2 gene
Catalog | Product Name | Application | Company |
GFS:E01565 | transcription factor CP2; ELISA kit | ELISA | n/a |
GFS:A01565 | transcription factor CP2; Anti | ANTIBODIES | n/a |
GFS:P01565 | transcription factor CP2; Protien | Protien | n/a |