Symbol: Name: ID: |
TLL1 tolloid-like 1 GFS:1657 |
Gene name: | TLL1 |
Chromosome: | 4q32-q33 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:106923 | Rat Genome Database ID: | |
HGNC ID: | HGNC:11843 | RefSeq IDs: | NM_012464 |
Entrez Gene ID: | 7092 | Ensembl Gene ID: | ENSG00000038295 |
VEGA IDs: | UniProt ID: | O43897 | |
UCSC ID: | uc003irh.1 | OMIM ID: | 606742 |
Pubmed: | PMID10516436 | ||
CCDS IDs: | CCDSCCDS3811.1 |
Tolloid-like protein 1 is a protein that in humans is encoded by the TLL1 gene. This gene encodes an astacin-like, zinc-dependent, metalloprotease that belongs to the peptidase M12A family. This protease processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Studies in mice suggest that this gene plays multiple roles in the development of mammalian heart, and is essential for the formation of the interventricular septum. Allelic variants of this gene are associated with atrial septal defect type 6. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.
Products for TLL1 gene
Catalog | Product Name | Application | Company |
GFS:E01657 | tolloid-like 1; ELISA kit | ELISA | n/a |
GFS:A01657 | tolloid-like 1; Anti | ANTIBODIES | n/a |
GFS:P01657 | tolloid-like 1; Protien | Protien | n/a |