Symbol: Name: ID: |
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein GFS:6279 |
Gene name: | TIRAP |
Chromosome: | 11q24.2 |
Previous Symbols: | |
Previous Names: | Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein |
Aliases: | Mal, wyatt |
Name Aliases: | MyD88 adapter-like |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2152213 | Rat Genome Database ID: | RGD:1595496 |
HGNC ID: | HGNC:17192 | RefSeq IDs: | NM_001039661 |
Entrez Gene ID: | 114609 | Ensembl Gene ID: | ENSG00000150455 |
VEGA IDs: | OTTHUMG00000140373 | UniProt ID: | P58753 |
UCSC ID: | uc001qdl.1 | OMIM ID: | 606252 |
Pubmed: | PMID11526399 PMID 11544529 | ||
CCDS IDs: | CCDSCCDS8472.1 CCDS CCDS41731.1 |
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008].
Function: Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.
Products for TIRAP gene
Catalog | Product Name | Application | Company |
GFS:E06279 | toll-interleukin 1 receptor (TIR) domain containing adaptor protein; ELISA kit | ELISA | n/a |
GFS:A06279 | toll-interleukin 1 receptor (TIR) domain containing adaptor protein; Anti | ANTIBODIES | n/a |
GFS:P06279 | toll-interleukin 1 receptor (TIR) domain containing adaptor protein; Protien | Protien | n/a |