Symbol: Name: ID: |
TOLLIP toll interacting protein GFS:5583 |
Gene name: | TOLLIP |
Chromosome: | 11p |
Previous Symbols: | |
Previous Names: | |
Aliases: | IL-1RAcPIP |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1891808 | Rat Genome Database ID: | RGD:1304676 |
HGNC ID: | HGNC:16476 | RefSeq IDs: | NM_019009 |
Entrez Gene ID: | 54472 | Ensembl Gene ID: | ENSG00000078902 |
VEGA IDs: | OTTHUMG00000133333 | UniProt ID: | Q9H0E2 |
UCSC ID: | uc001lte.2 | OMIM ID: | 606277 |
Pubmed: | PMID9426216 PMID 10854325 | ||
CCDS IDs: | CCDSCCDS7723.1 |
Toll interacting protein, also known as TOLLIP, is an inhibitory adaptor protein that in humans is encoded by the TOLLIP gene.
This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. [provided by RefSeq, Aug 2011]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity.
Products for TOLLIP gene
Catalog | Product Name | Application | Company |
GFS:E05583 | toll interacting protein; ELISA kit | ELISA | n/a |
GFS:A05583 | toll interacting protein; Anti | ANTIBODIES | n/a |
GFS:P05583 | toll interacting protein; Protien | Protien | n/a |