Symbol: Name: ID: |
TEF thyrotrophic embryonic factor GFS:1540 |
Gene name: | TEF |
Chromosome: | 22q13.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA1655 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98663 | Rat Genome Database ID: | RGD:3841 |
HGNC ID: | HGNC:11722 | RefSeq IDs: | NM_001145398 |
Entrez Gene ID: | 7008 | Ensembl Gene ID: | ENSG00000167074 |
VEGA IDs: | OTTHUMG00000150968 | UniProt ID: | Q10587 |
UCSC ID: | uc003azy.2 | OMIM ID: | 188595 |
Pubmed: | PMID7835883 PMID 15665112 | ||
CCDS IDs: | CCDSCCDS14014.1 CCDS CCDS46716.1 |
Thyrotroph embryonic factor is a protein that in humans is encoded by the TEF gene. Thyrotroph embryonic factor (TEF), a transcription factor, is a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'.
Products for TEF gene
Catalog | Product Name | Application | Company |
GFS:E01540 | thyrotrophic embryonic factor; ELISA kit | ELISA | n/a |
GFS:A01540 | thyrotrophic embryonic factor; Anti | ANTIBODIES | n/a |
GFS:P01540 | thyrotrophic embryonic factor; Protien | Protien | n/a |