Symbol: Name: ID: |
TPO thyroid peroxidase GFS:1815 |
Gene name: | TPO |
Chromosome: | 2p25 |
Previous Symbols: | |
Previous Names: | |
Aliases: | TPX |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98813 | Rat Genome Database ID: | RGD:3900 |
HGNC ID: | HGNC:12015 | RefSeq IDs: | NM_000547 |
Entrez Gene ID: | 7173 | Ensembl Gene ID: | ENSG00000115705 |
VEGA IDs: | OTTHUMG00000090271 | UniProt ID: | P07202 |
UCSC ID: | uc002qww.2 | OMIM ID: | 606765 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS1643.1 CCDS CCDS1644.1 CCDS CCDS1646.1 |
The TPO encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq].
Function: Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
Products for TPO gene
Catalog | Product Name | Application | Company |
GFS:E01815 | thyroid peroxidase; ELISA kit | ELISA | n/a |
GFS:A01815 | thyroid peroxidase; Anti | ANTIBODIES | n/a |
GFS:P01815 | thyroid peroxidase; Protien | Protien | n/a |