Symbol: Name: ID: |
THRB thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian) GFS:1613 |
Gene name: | THRB |
Chromosome: | 3p24.2 |
Previous Symbols: | ERBA2, PRTH |
Previous Names: | thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2), "pituitary resistance to thyroid hormone" |
Aliases: | THRB1, THRB2, NR1A2, THR1, ERBA-BETA, GRTH |
Name Aliases: | avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98743 | Rat Genome Database ID: | RGD:3858 |
HGNC ID: | HGNC:11799 | RefSeq IDs: | NM_000461 |
Entrez Gene ID: | 7068 | Ensembl Gene ID: | ENSG00000151090 |
VEGA IDs: | OTTHUMG00000130478 | UniProt ID: | P10828 |
UCSC ID: | uc003ccx.3 | OMIM ID: | 190160 |
Pubmed: | PMID1973914 PMID 8040303 | ||
CCDS IDs: | CCDSCCDS2641.1 |
Thyroid hormone receptor beta (TR-beta) also known as nuclear receptor subfamily 1, group A, member 2 (NR1A2), is a nuclear receptor protein that in humans is encoded by the THRB gene. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq].
Function: High affinity receptor for triiodothyronine.
Products for THRB gene
Catalog | Product Name | Application | Company |
GFS:E01613 | thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian); ELISA kit | ELISA | n/a |
GFS:A01613 | thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian); Anti | ANTIBODIES | n/a |
GFS:P01613 | thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian); Protien | Protien | n/a |