Symbol: Name: ID: |
TYMS thymidylate synthetase GFS:2237 |
Gene name: | TYMS |
Chromosome: | 18p11.31-p11.21 |
Previous Symbols: | TS |
Previous Names: | |
Aliases: | Tsase, TMS, HsT422 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98878 | Rat Genome Database ID: | |
HGNC ID: | HGNC:12441 | RefSeq IDs: | NM_001071 |
Entrez Gene ID: | 7298 | Ensembl Gene ID: | ENSG00000176890 |
VEGA IDs: | OTTHUMG00000131473 | UniProt ID: | P04818 |
UCSC ID: | uc010dka.1 | OMIM ID: | 188350 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS11821.1 |
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Products for TYMS gene
Catalog | Product Name | Application | Company |
GFS:E02237 | thymidylate synthetase; ELISA kit | ELISA | n/a |
GFS:A02237 | thymidylate synthetase; Anti | ANTIBODIES | n/a |
GFS:P02237 | thymidylate synthetase; Protien | Protien | n/a |