Symbol: Name: ID: |
THBD thrombomodulin GFS:1602 |
Gene name: | THBD |
Chromosome: | 20p12-cen |
Previous Symbols: | |
Previous Names: | |
Aliases: | CD141 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98736 | Rat Genome Database ID: | RGD:621299 |
HGNC ID: | HGNC:11784 | RefSeq IDs: | NM_000361 |
Entrez Gene ID: | 7056 | Ensembl Gene ID: | ENSG00000178726 |
VEGA IDs: | OTTHUMG00000032053 | UniProt ID: | P07204 |
UCSC ID: | uc002wss.2 | OMIM ID: | 188040 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS13148.1 |
Thrombomodulin, CD141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells. In humans, thrombomodulin is encoded by the THBD gene. The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
Products for THBD gene
Catalog | Product Name | Application | Company |
GFS:E01602 | thrombomodulin; ELISA kit | ELISA | n/a |
GFS:A01602 | thrombomodulin; Anti | ANTIBODIES | n/a |
GFS:P01602 | thrombomodulin; Protien | Protien | n/a |