Symbol: Name: ID: |
TREX1 three prime repair exonuclease 1 GFS:2084 |
Gene name: | TREX1 |
Chromosome: | 3p21.31 |
Previous Symbols: | AGS1 |
Previous Names: | Aicardi-Goutieres syndrome 1 |
Aliases: | DRN3 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1328317 | Rat Genome Database ID: | |
HGNC ID: | HGNC:12269 | RefSeq IDs: | NM_016381 |
Entrez Gene ID: | 11277 | Ensembl Gene ID: | ENSG00000213689 |
VEGA IDs: | OTTHUMG00000156205 | UniProt ID: | Q9NSU2 |
UCSC ID: | uc010hka.2 | OMIM ID: | 606609 |
Pubmed: | PMID10391904 PMID 10393201 PMID 16845398 | ||
CCDS IDs: | CCDSCCDS2769.1 CCDS CCDS43086.1 |
Three prime repair exonuclease 1 is an enzyme that in humans is encoded by the TREX1 gene. This gene encodes the major 3'->5' DNA exonuclease in human cells. The protein is a non-processive exonuclease that may serve a proofreading function for a human DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3' ends of nicked DNA during granzyme A-mediated cell death. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Function: Exonuclease with a preference for double stranded DNA with mismatched 3' termini. May play a role in DNA repair.
Products for TREX1 gene
Catalog | Product Name | Application | Company |
GFS:E02084 | three prime repair exonuclease 1; ELISA kit | ELISA | n/a |
GFS:A02084 | three prime repair exonuclease 1; Anti | ANTIBODIES | n/a |
GFS:P02084 | three prime repair exonuclease 1; Protien | Protien | n/a |