Symbol: Name: ID: |
THEM4 thioesterase superfamily member 4 GFS:6846 |
Gene name: | THEM4 |
Chromosome: | 1q21.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CTMP |
Name Aliases: | C-terminal modulator protein |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1923028 | Rat Genome Database ID: | RGD:1304723 |
HGNC ID: | HGNC:17947 | RefSeq IDs: | NM_053055 |
Entrez Gene ID: | 117145 | Ensembl Gene ID: | ENSG00000159445 |
VEGA IDs: | OTTHUMG00000013049 | UniProt ID: | Q5T1C6 |
UCSC ID: | uc001ezj.1 | OMIM ID: | 606388 |
Pubmed: | PMID11598301 | ||
CCDS IDs: | CCDSCCDS1006.1 |
Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq, Jul 2008].
Function: According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane.
Products for THEM4 gene
Catalog | Product Name | Application | Company |
GFS:E06846 | thioesterase superfamily member 4; ELISA kit | ELISA | n/a |
GFS:A06846 | thioesterase superfamily member 4; Anti | ANTIBODIES | n/a |
GFS:P06846 | thioesterase superfamily member 4; Protien | Protien | n/a |