Symbol: Name: ID: |
TTC3 tetratricopeptide repeat domain 3 GFS:2195 |
Gene name: | TTC3 |
Chromosome: | 21q22.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | TPRD, TPRDI, DCRR1, TPRDII, TPRDIII, RNF105 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1276539 | Rat Genome Database ID: | |
HGNC ID: | HGNC:12393 | RefSeq IDs: | NM_001001894 |
Entrez Gene ID: | 7267 | Ensembl Gene ID: | ENSG00000182670 |
VEGA IDs: | OTTHUMG00000086654 | UniProt ID: | P53804 |
UCSC ID: | uc002yvz.2 | OMIM ID: | 602259 |
Pubmed: | PMID8947847 | ||
CCDS IDs: | CCDSCCDS13651.1 |
Tetratricopeptide repeat protein 3 is a protein that in humans is encoded by the TTC3 gene. E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.
Products for TTC3 gene
Catalog | Product Name | Application | Company |
GFS:E02195 | tetratricopeptide repeat domain 3; ELISA kit | ELISA | n/a |
GFS:A02195 | tetratricopeptide repeat domain 3; Anti | ANTIBODIES | n/a |
GFS:P02195 | tetratricopeptide repeat domain 3; Protien | Protien | n/a |