Symbol: Name: ID: |
TNXB tenascin XB GFS:1780 |
Gene name: | TNXB |
Chromosome: | 6p21.3 |
Previous Symbols: | TNXB1, TNXB2 |
Previous Names: | |
Aliases: | TNXBS, XBS, XB |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1932137 | Rat Genome Database ID: | |
HGNC ID: | HGNC:11976 | RefSeq IDs: | NM_019105 |
Entrez Gene ID: | 7148 | Ensembl Gene ID: | |
VEGA IDs: | UniProt ID: | P22105 | |
UCSC ID: | uc011dpc.1 | OMIM ID: | 600985 |
Pubmed: | PMID8530023 | ||
CCDS IDs: | CCDSCCDS4736.1 |
The TNXB encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Function: Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors.
Products for TNXB gene
Catalog | Product Name | Application | Company |
GFS:E01780 | tenascin XB; ELISA kit | ELISA | n/a |
GFS:A01780 | tenascin XB; Anti | ANTIBODIES | n/a |
GFS:P01780 | tenascin XB; Protien | Protien | n/a |