Symbol: Name: ID: |
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 GFS:1546 |
Gene name: | TERF1 |
Chromosome: | 8q13 |
Previous Symbols: | TRBF1 |
Previous Names: | |
Aliases: | PIN2, TRF1, TRF |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:109634 | Rat Genome Database ID: | RGD:1311574 |
HGNC ID: | HGNC:11728 | RefSeq IDs: | NM_003218 |
Entrez Gene ID: | 7013 | Ensembl Gene ID: | ENSG00000147601 |
VEGA IDs: | OTTHUMG00000139498 | UniProt ID: | P54274 |
UCSC ID: | uc003xzd.2 | OMIM ID: | 600951 |
Pubmed: | PMID9391075 | ||
CCDS IDs: | CCDSCCDS6210.1 CCDS CCDS6211.1 |
Telomeric repeat-binding factor 1 is a protein that in humans is encoded by the TERF1 gene. This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq].
Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
Products for TERF1 gene
Catalog | Product Name | Application | Company |
GFS:E01546 | telomeric repeat binding factor (NIMA-interacting) 1; ELISA kit | ELISA | n/a |
GFS:A01546 | telomeric repeat binding factor (NIMA-interacting) 1; Anti | ANTIBODIES | n/a |
GFS:P01546 | telomeric repeat binding factor (NIMA-interacting) 1; Protien | Protien | n/a |