Symbol: Name: ID: |
TERT telomerase reverse transcriptase GFS:1549 |
Gene name: | TERT |
Chromosome: | 5p15.33 |
Previous Symbols: | |
Previous Names: | |
Aliases: | TRT, TP2, TCS1, hEST2, EST2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1202709 | Rat Genome Database ID: | RGD:70494 |
HGNC ID: | HGNC:11730 | RefSeq IDs: | NM_001193376 |
Entrez Gene ID: | 7015 | Ensembl Gene ID: | ENSG00000164362 |
VEGA IDs: | OTTHUMG00000090357 | UniProt ID: | O14746 |
UCSC ID: | uc003jcb.1 | OMIM ID: | 187270 |
Pubmed: | PMID9252327 | ||
CCDS IDs: | CCDSCCDS3861.2 |
Telomerase reverse transcriptase (abbreviated to TERT, or hTERT in humans) is a catalytic subunit of the enzyme telomerase.Its absence (usually as a result of a chromosomal mutation) is associated with the disorder Cri du chat Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq].
Products for TERT gene
Catalog | Product Name | Application | Company |
GFS:E01549 | telomerase reverse transcriptase; ELISA kit | ELISA | n/a |
GFS:A01549 | telomerase reverse transcriptase; Anti | ANTIBODIES | n/a |
GFS:P01549 | telomerase reverse transcriptase; Protien | Protien | n/a |