Symbol: Name: ID: |
TCP1 t-complex 1 GFS:1500 |
Gene name: | TCP1 |
Chromosome: | 6q25-q27 |
Previous Symbols: | |
Previous Names: | |
Aliases: | D6S230E, CCT1, Ccta |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98535 | Rat Genome Database ID: | RGD:3832 |
HGNC ID: | HGNC:11655 | RefSeq IDs: | NM_001008897 |
Entrez Gene ID: | 6950 | Ensembl Gene ID: | ENSG00000120438 |
VEGA IDs: | OTTHUMG00000015937 | UniProt ID: | P17987 |
UCSC ID: | uc003qsr.2 | OMIM ID: | 186980 |
Pubmed: | PMID3476253 PMID 3653076 | ||
CCDS IDs: | CCDSCCDS5269.1 CCDS CCDS43522.1 |
T-complex protein 1 subunit alpha is a protein that in humans is encoded by the TCP1 gene. The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. [provided by RefSeq].
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.
Products for TCP1 gene
Catalog | Product Name | Application | Company |
GFS:E01500 | t-complex 1; ELISA kit | ELISA | n/a |
GFS:A01500 | t-complex 1; Anti | ANTIBODIES | n/a |
GFS:P01500 | t-complex 1; Protien | Protien | n/a |