Symbol: Name: ID: |
SNCB synuclein, beta GFS:1047 |
Gene name: | SNCB |
Chromosome: | 5q35 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1889011 | Rat Genome Database ID: | RGD:70992 |
HGNC ID: | HGNC:11140 | RefSeq IDs: | NM_001001502 |
Entrez Gene ID: | 6620 | Ensembl Gene ID: | ENSG00000074317 |
VEGA IDs: | OTTHUMG00000130661 | UniProt ID: | Q16143 |
UCSC ID: | uc003meq.2 | OMIM ID: | 602569 |
Pubmed: | PMID7558013 PMID 9806846 | ||
CCDS IDs: | CCDSCCDS4406.1 |
Beta-synuclein is a protein that in humans is encoded by the SNCB gene. The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
Products for SNCB gene
Catalog | Product Name | Application | Company |
GFS:E01047 | synuclein, beta; ELISA kit | ELISA | n/a |
GFS:A01047 | synuclein, beta; Anti | ANTIBODIES | n/a |
GFS:P01047 | synuclein, beta; Protien | Protien | n/a |