Symbol: Name: ID: |
SNCAIP synuclein, alpha interacting protein GFS:1046 |
Gene name: | SNCAIP |
Chromosome: | 5q23.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | SYPH1 |
Name Aliases: | synphilin |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1915097 | Rat Genome Database ID: | RGD:1309283 |
HGNC ID: | HGNC:11139 | RefSeq IDs: | NM_005460 |
Entrez Gene ID: | 9627 | Ensembl Gene ID: | ENSG00000064692 |
VEGA IDs: | OTTHUMG00000128915 | UniProt ID: | Q9Y6H5 |
UCSC ID: | uc003ksw.1 | OMIM ID: | 603779 |
Pubmed: | PMID10319874 | ||
CCDS IDs: | CCDSCCDS4131.1 |
Synphilin-1 is a protein that in humans is encoded by the SNCAIP gene. This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternatively spliced transcript variants encoding different isoforms of this gene have been described, but their full-length nature has yet to be determined. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1.
Products for SNCAIP gene
Catalog | Product Name | Application | Company |
GFS:E01046 | synuclein, alpha interacting protein; ELISA kit | ELISA | n/a |
GFS:A01046 | synuclein, alpha interacting protein; Anti | ANTIBODIES | n/a |
GFS:P01046 | synuclein, alpha interacting protein; Protien | Protien | n/a |