Symbol: Name: ID: |
SDCBP syndecan binding protein (syntenin) GFS:585 |
Gene name: | SDCBP |
Chromosome: | 8q12 |
Previous Symbols: | |
Previous Names: | |
Aliases: | SYCL |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1337026 | Rat Genome Database ID: | RGD:621497 |
HGNC ID: | HGNC:10662 | RefSeq IDs: | NM_001007067 |
Entrez Gene ID: | 6386 | Ensembl Gene ID: | ENSG00000137575 |
VEGA IDs: | UniProt ID: | O00560 | |
UCSC ID: | uc003xtq.2 | OMIM ID: | 602217 |
Pubmed: | PMID9391086 | ||
CCDS IDs: | CCDSCCDS6172.1 CCDS CCDS47862.1 CCDS CCDS47863.1 |
Syntenin-1 is a protein that in humans is encoded by the SDCBP gene.The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].
Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway
Products for SDCBP gene
Catalog | Product Name | Application | Company |
GFS:E00585 | syndecan binding protein (syntenin); ELISA kit | ELISA | n/a |
GFS:A00585 | syndecan binding protein (syntenin); Anti | ANTIBODIES | n/a |
GFS:P00585 | syndecan binding protein (syntenin); Protien | Protien | n/a |