Symbol: Name: ID: |
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) GFS:6370 |
Gene name: | SUV39H2 |
Chromosome: | 10p13 |
Previous Symbols: | |
Previous Names: | |
Aliases: | FLJ23414, KMT1B |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1890396 | Rat Genome Database ID: | RGD:1306969 |
HGNC ID: | HGNC:17287 | RefSeq IDs: | NM_001193424 |
Entrez Gene ID: | 79723 | Ensembl Gene ID: | ENSG00000152455 |
VEGA IDs: | OTTHUMG00000017718 | UniProt ID: | Q9H5I1 |
UCSC ID: | uc001inj.2 | OMIM ID: | 606503 |
Pubmed: | PMID11094092 | ||
CCDS IDs: | CCDSCCDS7104.1 |
Histone-lysine N-methyltransferase SUV39H2 is an enzyme that in humans is encoded by the SUV39H2 gene.
Function: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher order chromatin organization during spermatogenesis.
Products for SUV39H2 gene
Catalog | Product Name | Application | Company |
GFS:E06370 | suppressor of variegation 3-9 homolog 2 (Drosophila); ELISA kit | ELISA | n/a |
GFS:A06370 | suppressor of variegation 3-9 homolog 2 (Drosophila); Anti | ANTIBODIES | n/a |
GFS:P06370 | suppressor of variegation 3-9 homolog 2 (Drosophila); Protien | Protien | n/a |