Symbol: Name: ID: |
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) GFS:600 |
Gene name: | SDHB |
Chromosome: | 1p36.1-p35 |
Previous Symbols: | SDH1, SDH |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1914930 | Rat Genome Database ID: | RGD:1308598 |
HGNC ID: | HGNC:10681 | RefSeq IDs: | NM_003000 |
Entrez Gene ID: | 6390 | Ensembl Gene ID: | ENSG00000117118 |
VEGA IDs: | OTTHUMG00000002289 | UniProt ID: | P21912 |
UCSC ID: | uc001bae.2 | OMIM ID: | 185470 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS176.1 |
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)
Products for SDHB gene
Catalog | Product Name | Application | Company |
GFS:E00600 | succinate dehydrogenase complex, subunit B, iron sulfur (Ip); ELISA kit | ELISA | n/a |
GFS:A00600 | succinate dehydrogenase complex, subunit B, iron sulfur (Ip); Anti | ANTIBODIES | n/a |
GFS:P00600 | succinate dehydrogenase complex, subunit B, iron sulfur (Ip); Protien | Protien | n/a |