Symbol: Name: ID: |
SOAT2 sterol O-acyltransferase 2 GFS:1076 |
Gene name: | SOAT2 |
Chromosome: | 12 |
Previous Symbols: | |
Previous Names: | |
Aliases: | ACAT2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1332226 | Rat Genome Database ID: | RGD:628865 |
HGNC ID: | HGNC:11178 | RefSeq IDs: | NM_003578 |
Entrez Gene ID: | 8435 | Ensembl Gene ID: | ENSG00000167780 |
VEGA IDs: | UniProt ID: | O75908 | |
UCSC ID: | uc001sbv.2 | OMIM ID: | 601311 |
Pubmed: | PMID9756920 | ||
CCDS IDs: | CCDSCCDS8847.1 |
Sterol O-acyltransferase 2, also known as SOAT2, is an enzyme which in humans is encoded by the SOAT2 gene. This gene is a member of a small family of acyl coenzyme A:cholesterol acyltransferases. The gene encodes a membrane-bound enzyme localized in the endoplasmic reticulum that produces intracellular cholesterol esters from long-chain fatty acyl CoA and cholesterol. The cholesterol esters are then stored as cytoplasmic lipid droplets inside the cell. The enzyme is implicated in cholesterol absorption in the intestine and in the assembly and secretion of apolipoprotein B-containing lipoproteins such as very low density lipoprotein (VLDL). Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.
Products for SOAT2 gene
Catalog | Product Name | Application | Company |
GFS:E01076 | sterol O-acyltransferase 2; ELISA kit | ELISA | n/a |
GFS:A01076 | sterol O-acyltransferase 2; Anti | ANTIBODIES | n/a |
GFS:P01076 | sterol O-acyltransferase 2; Protien | Protien | n/a |