Symbol: Name: ID: |
SLBP stem-loop binding protein GFS:813 |
Gene name: | SLBP |
Chromosome: | 4p16.3 |
Previous Symbols: | |
Previous Names: | stem-loop (histone) binding protein |
Aliases: | HBP |
Name Aliases: | histone binding protein |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:108402 | Rat Genome Database ID: | RGD:1584682 |
HGNC ID: | HGNC:10904 | RefSeq IDs: | NM_006527 |
Entrez Gene ID: | 7884 | Ensembl Gene ID: | ENSG00000163950 |
VEGA IDs: | OTTHUMG00000089349 | UniProt ID: | Q14493 |
UCSC ID: | uc003gdi.1 | OMIM ID: | 602422 |
Pubmed: | PMID9049306 PMID 1338771 | ||
CCDS IDs: | CCDSCCDS3350.1 |
Histone RNA hairpin-binding protein is a protein that in humans is encoded by the SLBP gene. This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
RNA-binding protein involved in the histone pre-mRNA processing. Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery. Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression. Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis. Binds to the 5' side of the stem-loop structure of histone pre-mRNAs.
Products for SLBP gene
Catalog | Product Name | Application | Company |
GFS:E00813 | stem-loop binding protein; ELISA kit | ELISA | n/a |
GFS:A00813 | stem-loop binding protein; Anti | ANTIBODIES | n/a |
GFS:P00813 | stem-loop binding protein; Protien | Protien | n/a |