Symbol: Name: ID: |
SKAP1 src kinase associated phosphoprotein 1 GFS:4798 |
Gene name: | SKAP1 |
Chromosome: | 17q21.32 |
Previous Symbols: | SCAP1 |
Previous Names: | src family associated phosphoprotein 1 |
Aliases: | SKAP55 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1925723 | Rat Genome Database ID: | RGD:708436 |
HGNC ID: | HGNC:15605 | RefSeq IDs: | NM_001075099 |
Entrez Gene ID: | 8631 | Ensembl Gene ID: | ENSG00000141293 |
VEGA IDs: | UniProt ID: | Q86WV1 | |
UCSC ID: | uc002ini.1 | OMIM ID: | 604969 |
Pubmed: | PMID9195899 | ||
CCDS IDs: | CCDSCCDS32674.1 |
Src kinase-associated phosphoprotein 1 is an adapter protein that in humans is encoded by the SKAP1 gene.
This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq, Jul 2008].
Function: Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.
Products for SKAP1 gene
Catalog | Product Name | Application | Company |
GFS:E04798 | src kinase associated phosphoprotein 1; ELISA kit | ELISA | n/a |
GFS:A04798 | src kinase associated phosphoprotein 1; Anti | ANTIBODIES | n/a |
GFS:P04798 | src kinase associated phosphoprotein 1; Protien | Protien | n/a |