Symbol: Name: ID: |
SPRY4 sprouty homolog 4 (Drosophila) GFS:4740 |
Gene name: | SPRY4 |
Chromosome: | 5q31.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1345144 | Rat Genome Database ID: | RGD:1305324 |
HGNC ID: | HGNC:15533 | RefSeq IDs: | NM_001127496 |
Entrez Gene ID: | 81848 | Ensembl Gene ID: | ENSG00000187678 |
VEGA IDs: | OTTHUMG00000129663 | UniProt ID: | Q9C004 |
UCSC ID: | uc003lml.2 | OMIM ID: | 607984 |
Pubmed: | PMID16465403 | ||
CCDS IDs: | CCDSCCDS4274.1 CCDS CCDS47296.1 |
Protein sprouty homolog 4 is a protein that in humans is encoded by the SPRY4 gene.
SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002 [PubMed 12027893]).[supplied by OMIM, Mar 2008].
Function: Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras.
Products for SPRY4 gene
Catalog | Product Name | Application | Company |
GFS:E04740 | sprouty homolog 4 (Drosophila); ELISA kit | ELISA | n/a |
GFS:A04740 | sprouty homolog 4 (Drosophila); Anti | ANTIBODIES | n/a |
GFS:P04740 | sprouty homolog 4 (Drosophila); Protien | Protien | n/a |