Symbol: Name: ID: |
SYK spleen tyrosine kinase GFS:1352 |
Gene name: | SYK |
Chromosome: | 9q22 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:99515 | Rat Genome Database ID: | RGD:3796 |
HGNC ID: | HGNC:11491 | RefSeq IDs: | NM_001135052 |
Entrez Gene ID: | 6850 | Ensembl Gene ID: | ENSG00000165025 |
VEGA IDs: | OTTHUMG00000020200 | UniProt ID: | P43405 |
UCSC ID: | uc004aqz.2 | OMIM ID: | 600085 |
Pubmed: | PMID8082894 PMID 1423621 | ||
CCDS IDs: | CCDSCCDS6688.1 CCDS CCDS47992.1 |
Spleen tyrosine kinase, also known as Syk, is an enyzme which in humans is encoded by the SYK gene. This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-348 and Tyr-352. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion (By similarity). Phosphorylates USP25 and regulates its intracellular levels.
Products for SYK gene
Catalog | Product Name | Application | Company |
GFS:E01352 | spleen tyrosine kinase; ELISA kit | ELISA | n/a |
GFS:A01352 | spleen tyrosine kinase; Anti | ANTIBODIES | n/a |
GFS:P01352 | spleen tyrosine kinase; Protien | Protien | n/a |