Symbol: Name: ID: |
S1PR5 sphingosine-1-phosphate receptor 5 GFS:3661 |
Gene name: | S1PR5 |
Chromosome: | 19p13.2 |
Previous Symbols: | EDG8 |
Previous Names: | endothelial differentiation, sphingolipid G-protein-coupled receptor, 8 |
Aliases: | Edg-8 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2150641 | Rat Genome Database ID: | RGD:620566 |
HGNC ID: | HGNC:14299 | RefSeq IDs: | NM_001166215 |
Entrez Gene ID: | 53637 | Ensembl Gene ID: | ENSG00000180739 |
VEGA IDs: | UniProt ID: | Q9H228 | |
UCSC ID: | uc002mot.1 | OMIM ID: | 605146 |
Pubmed: | PMID10799507 | ||
CCDS IDs: | CCDSCCDS12240.1 |
Sphingosine-1-phosphate receptor 5 also known as S1PR5 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P5.
The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008].
Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.
Products for S1PR5 gene
Catalog | Product Name | Application | Company |
GFS:E03661 | sphingosine-1-phosphate receptor 5; ELISA kit | ELISA | n/a |
GFS:A03661 | sphingosine-1-phosphate receptor 5; Anti | ANTIBODIES | n/a |
GFS:P03661 | sphingosine-1-phosphate receptor 5; Protien | Protien | n/a |