Symbol: Name: ID: |
SMOX spermine oxidase GFS:5000 |
Gene name: | SMOX |
Chromosome: | 20p13 |
Previous Symbols: | C20orf16 |
Previous Names: | chromosome 20 open reading frame 16 |
Aliases: | FLJ20746, dJ779E11.1, PAO, PAOh1, MGC1010, SMO |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2445356 | Rat Genome Database ID: | RGD:1306049 |
HGNC ID: | HGNC:15862 | RefSeq IDs: | NM_175839 |
Entrez Gene ID: | 54498 | Ensembl Gene ID: | ENSG00000088826 |
VEGA IDs: | OTTHUMG00000031777 | UniProt ID: | Q9NWM0 |
UCSC ID: | uc002wkm.1 | OMIM ID: | |
Pubmed: | PMID11454677 PMID 12398765 | ||
CCDS IDs: | CCDSCCDS13075.1 CCDS CCDS13076.1 CCDS CCDS13077.1 CCDS CCDS13078.1 |
Spermine oxidase is an enzyme that in humans is encoded by the SMOX gene.
The product of this gene is the polyamine oxidase. This enzyme potentially represents a new class of catabolic enzymes in the mammalian polyamine metabolic pathway capable of the efficient oxidation of polyamines. More than five transcript variants encoding four active isoenzymes have been identified for this gene, however, not all variants have been fully described. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism. [provided by RefSeq, Jul 2008].
Function: Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.
Products for SMOX gene
Catalog | Product Name | Application | Company |
GFS:E05000 | spermine oxidase; ELISA kit | ELISA | n/a |
GFS:A05000 | spermine oxidase; Anti | ANTIBODIES | n/a |
GFS:P05000 | spermine oxidase; Protien | Protien | n/a |