Symbol: Name: ID: |
SPACA1 sperm acrosome associated 1 GFS:4247 |
Gene name: | SPACA1 |
Chromosome: | 6pter-6q22.33 |
Previous Symbols: | |
Previous Names: | |
Aliases: | SAMP32 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1914902 | Rat Genome Database ID: | RGD:1560284 |
HGNC ID: | HGNC:14967 | RefSeq IDs: | NM_030960 |
Entrez Gene ID: | 81833 | Ensembl Gene ID: | ENSG00000118434 |
VEGA IDs: | OTTHUMG00000015183 | UniProt ID: | Q9HBV2 |
UCSC ID: | uc003pmn.2 | OMIM ID: | 612739 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS5014.1 |
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from infertile males. Furthermore, antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Function: May be involved in sperm-egg fusion.
Products for SPACA1 gene
Catalog | Product Name | Application | Company |
GFS:E04247 | sperm acrosome associated 1; ELISA kit | ELISA | n/a |
GFS:A04247 | sperm acrosome associated 1; Anti | ANTIBODIES | n/a |
GFS:P04247 | sperm acrosome associated 1; Protien | Protien | n/a |