Symbol: Name: ID: |
SPTB spectrin, beta, erythrocytic GFS:1167 |
Gene name: | SPTB |
Chromosome: | 14q24.1-q24.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | spherocytosis, clinical type I |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98387 | Rat Genome Database ID: | RGD:1303243 |
HGNC ID: | HGNC:11274 | RefSeq IDs: | NM_000347 |
Entrez Gene ID: | 6710 | Ensembl Gene ID: | ENSG00000070182 |
VEGA IDs: | UniProt ID: | P11277 | |
UCSC ID: | uc001xhr.2 | OMIM ID: | 182870 |
Pubmed: | PMID2209094 | ||
CCDS IDs: | CCDSCCDS32099.1 CCDS CCDS32100.1 |
Spectrin beta chain, erythrocyte is a protein that in humans is encoded by the SPTB gene. This locus encodes a member of the spectrin gene family. Spectrin proteins, along with ankyrin, play a role in cell membrane organization and stability. The protein encoded by this locus functions in stability of erythrocyte membranes, and mutations in this gene have been associated with spherocytosis type 2, hereditary elliptocytosis, and neonatal hemolytic anemia. Alternatively spliced transcript variants have been described. [provided by RefSeq].
Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
Products for SPTB gene
Catalog | Product Name | Application | Company |
GFS:E01167 | spectrin, beta, erythrocytic; ELISA kit | ELISA | n/a |
GFS:A01167 | spectrin, beta, erythrocytic; Anti | ANTIBODIES | n/a |
GFS:P01167 | spectrin, beta, erythrocytic; Protien | Protien | n/a |