Symbol: Name: ID: |
SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) GFS:1166 |
Gene name: | SPTAN1 |
Chromosome: | 9q34.11 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98386 | Rat Genome Database ID: | RGD:621714 |
HGNC ID: | HGNC:11273 | RefSeq IDs: | NM_001130438 |
Entrez Gene ID: | 6709 | Ensembl Gene ID: | ENSG00000197694 |
VEGA IDs: | OTTHUMG00000020754 | UniProt ID: | Q13813 |
UCSC ID: | uc004bvm.3 | OMIM ID: | 182810 |
Pubmed: | PMID3336352 | ||
CCDS IDs: | CCDSCCDS6905.1 CCDS CCDS48036.1 |
Spectrin alpha chain, brain is a protein that in humans is encoded by the SPTAN1 gene. Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
Products for SPTAN1 gene
Catalog | Product Name | Application | Company |
GFS:E01166 | spectrin, alpha, non-erythrocytic 1 (alpha-fodrin); ELISA kit | ELISA | n/a |
GFS:A01166 | spectrin, alpha, non-erythrocytic 1 (alpha-fodrin); Anti | ANTIBODIES | n/a |
GFS:P01166 | spectrin, alpha, non-erythrocytic 1 (alpha-fodrin); Protien | Protien | n/a |