Symbol: Name: ID: |
SPOP speckle-type POZ protein GFS:1146 |
Gene name: | SPOP |
Chromosome: | 17q21.33 |
Previous Symbols: | |
Previous Names: | |
Aliases: | TEF2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1343085 | Rat Genome Database ID: | RGD:1311613 |
HGNC ID: | HGNC:11254 | RefSeq IDs: | NM_001007226 |
Entrez Gene ID: | 8405 | Ensembl Gene ID: | ENSG00000121067 |
VEGA IDs: | OTTHUMG00000161496 | UniProt ID: | O43791 |
UCSC ID: | uc002ipg.2 | OMIM ID: | 602650 |
Pubmed: | PMID9414087 | ||
CCDS IDs: | CCDSCCDS11551.1 |
Speckle-type POZ protein is a protein that in humans is encoded by the SPOP gene. This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq].
Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex (By similarity). In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3.
Products for SPOP gene
Catalog | Product Name | Application | Company |
GFS:E01146 | speckle-type POZ protein; ELISA kit | ELISA | n/a |
GFS:A01146 | speckle-type POZ protein; Anti | ANTIBODIES | n/a |
GFS:P01146 | speckle-type POZ protein; Protien | Protien | n/a |