Symbol: Name: ID: |
SORL1 sortilin-related receptor, L(DLR class) A repeats containing GFS:1084 |
Gene name: | SORL1 |
Chromosome: | 11q23.2-q24.4 |
Previous Symbols: | C11orf32 |
Previous Names: | chromosome 11 open reading frame 32, "sortilin-related receptor, L(DLR class) A repeats-containing" |
Aliases: | gp250, LR11, LRP9, SorLA, SorLA-1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1202296 | Rat Genome Database ID: | RGD:619914 |
HGNC ID: | HGNC:11185 | RefSeq IDs: | NM_003105 |
Entrez Gene ID: | 6653 | Ensembl Gene ID: | ENSG00000137642 |
VEGA IDs: | UniProt ID: | Q92673 | |
UCSC ID: | uc001pxx.2 | OMIM ID: | 602005 |
Pubmed: | PMID9157966 PMID 8940146 | ||
CCDS IDs: | CCDSCCDS8436.1 |
SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer's Disease. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction.
Products for SORL1 gene
Catalog | Product Name | Application | Company |
GFS:E01084 | sortilin-related receptor, L(DLR class) A repeats containing; ELISA kit | ELISA | n/a |
GFS:A01084 | sortilin-related receptor, L(DLR class) A repeats containing; Anti | ANTIBODIES | n/a |
GFS:P01084 | sortilin-related receptor, L(DLR class) A repeats containing; Protien | Protien | n/a |