Symbol: Name: ID: |
SORD sorbitol dehydrogenase GFS:1083 |
Gene name: | SORD |
Chromosome: | 15q15-q21.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98266 | Rat Genome Database ID: | RGD:3734 |
HGNC ID: | HGNC:11184 | RefSeq IDs: | NM_003104 |
Entrez Gene ID: | 6652 | Ensembl Gene ID: | ENSG00000140263 |
VEGA IDs: | OTTHUMG00000131265 | UniProt ID: | Q00796 |
UCSC ID: | uc001zul.3 | OMIM ID: | 182500 |
Pubmed: | PMID7782086 | ||
CCDS IDs: | CCDSCCDS10116.1 |
Sorbitol dehydrogenase is an enzyme that in humans is encoded by the SORD gene. Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM].
Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm (By similarity).
Products for SORD gene
Catalog | Product Name | Application | Company |
GFS:E01083 | sorbitol dehydrogenase; ELISA kit | ELISA | n/a |
GFS:A01083 | sorbitol dehydrogenase; Anti | ANTIBODIES | n/a |
GFS:P01083 | sorbitol dehydrogenase; Protien | Protien | n/a |