Symbol: Name: ID: |
SHH sonic hedgehog GFS:761 |
Gene name: | SHH |
Chromosome: | 7q36 |
Previous Symbols: | HPE3, HLP3 |
Previous Names: | sonic hedgehog (Drosophila) homolog, "sonic hedgehog homolog (Drosophila)" |
Aliases: | HHG1, SMMCI, TPT, TPTPS, MCOPCB5 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98297 | Rat Genome Database ID: | RGD:3673 |
HGNC ID: | HGNC:10848 | RefSeq IDs: | NM_000193 |
Entrez Gene ID: | 6469 | Ensembl Gene ID: | ENSG00000164690 |
VEGA IDs: | OTTHUMG00000151349 | UniProt ID: | Q15465 |
UCSC ID: | uc003wmk.1 | OMIM ID: | 600725 |
Pubmed: | PMID7590746 | ||
CCDS IDs: | CCDSCCDS5942.1 |
SHH encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Products for SHH gene
Catalog | Product Name | Application | Company |
GFS:E00761 | sonic hedgehog; ELISA kit | ELISA | n/a |
GFS:A00761 | sonic hedgehog; Anti | ANTIBODIES | n/a |
GFS:P00761 | sonic hedgehog; Protien | Protien | n/a |