Symbol: Name: ID: |
SHOC2 soc-2 suppressor of clear homolog (C. elegans) GFS:4664 |
Gene name: | SHOC2 |
Chromosome: | 10q25 |
Previous Symbols: | |
Previous Names: | soc-2 (suppressor of clear, C.elegans) homolog |
Aliases: | KIAA0862, SOC2, SUR-8, SOC-2, SUR8 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1927197 | Rat Genome Database ID: | RGD:1308146 |
HGNC ID: | HGNC:15454 | RefSeq IDs: | NM_007373 |
Entrez Gene ID: | 8036 | Ensembl Gene ID: | ENSG00000108061 |
VEGA IDs: | OTTHUMG00000019047 | UniProt ID: | Q9UQ13 |
UCSC ID: | uc001kzl.3 | OMIM ID: | 602775 |
Pubmed: | PMID9618511 PMID 9674433 PMID 10783161 | ||
CCDS IDs: | CCDSCCDS7568.1 |
Leucine-rich repeat protein SHOC-2 is a protein that in humans is encoded by the SHOC2 gene.
This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair. [provided by RefSeq, May 2010].
Function: Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.
Products for SHOC2 gene
Catalog | Product Name | Application | Company |
GFS:E04664 | soc-2 suppressor of clear homolog (C. elegans); ELISA kit | ELISA | n/a |
GFS:A04664 | soc-2 suppressor of clear homolog (C. elegans); Anti | ANTIBODIES | n/a |
GFS:P04664 | soc-2 suppressor of clear homolog (C. elegans); Protien | Protien | n/a |