Symbol: Name: ID: |
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 GFS:6235 |
Gene name: | SMUG1 |
Chromosome: | 12q13.11-q13.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | UNG3, FDG, HMUDG |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1918976 | Rat Genome Database ID: | RGD:631403 |
HGNC ID: | HGNC:17148 | RefSeq IDs: | NM_014311 |
Entrez Gene ID: | 23583 | Ensembl Gene ID: | ENSG00000123415 |
VEGA IDs: | UniProt ID: | Q53HV7 | |
UCSC ID: | uc001sff.1 | OMIM ID: | 607753 |
Pubmed: | PMID10074426 PMID 11526119 | ||
CCDS IDs: | CCDSCCDS8874.1 |
Single-strand selective monofunctional uracil DNA glycosylase is an enzyme that in humans is encoded by the SMUG1 gene.
This gene encodes a protein that participates in base excision repair by removing uracil from single- and double-stranded DNA. Many alternatively spliced transcript variants exist for this gene; the full-length nature is known for some but not all of the variants. [provided by RefSeq, Aug 2011].
Function: Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNA substrates. The activity is greater against mismatches (U/G) than against matches (U/A). Excised uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine) and other oxidized damage. The activity is damage specificity and salt concentration-dependent. The general order of the preference for ssDNA and dsDNA is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at the low salt concentration. At the high concentration dsDNA (G pair) > dsDNA (A pair) > ssDNA.
Products for SMUG1 gene
Catalog | Product Name | Application | Company |
GFS:E06235 | single-strand-selective monofunctional uracil-DNA glycosylase 1; ELISA kit | ELISA | n/a |
GFS:A06235 | single-strand-selective monofunctional uracil-DNA glycosylase 1; Anti | ANTIBODIES | n/a |
GFS:P06235 | single-strand-selective monofunctional uracil-DNA glycosylase 1; Protien | Protien | n/a |