Symbol: Name: ID: |
SIAH1 seven in absentia homolog 1 (Drosophila) GFS:769 |
Gene name: | SIAH1 |
Chromosome: | 16q12 |
Previous Symbols: | |
Previous Names: | |
Aliases: | hSIAH1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:108064 | Rat Genome Database ID: | RGD:620449 |
HGNC ID: | HGNC:10857 | RefSeq IDs: | NM_001006610 |
Entrez Gene ID: | 6477 | Ensembl Gene ID: | ENSG00000196470 |
VEGA IDs: | OTTHUMG00000133145 | UniProt ID: | Q8IUQ4 |
UCSC ID: | uc002efk.1 | OMIM ID: | 602212 |
Pubmed: | PMID9403064 PMID 9334332 | ||
CCDS IDs: | CCDSCCDS10735.1 CCDS CCDS32444.1 |
E3 ubiquitin-protein ligase SIAH1 is an enzyme that in humans is encoded by the SIAH1 gene. This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. (provided by RefSeq)
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes.
Products for SIAH1 gene
Catalog | Product Name | Application | Company |
GFS:E00769 | seven in absentia homolog 1 (Drosophila); ELISA kit | ELISA | n/a |
GFS:A00769 | seven in absentia homolog 1 (Drosophila); Anti | ANTIBODIES | n/a |
GFS:P00769 | seven in absentia homolog 1 (Drosophila); Protien | Protien | n/a |