Symbol: Name: ID: |
SARS2 seryl-tRNA synthetase 2, mitochondrial GFS:6629 |
Gene name: | SARS2 |
Chromosome: | 19q13.2 |
Previous Symbols: | SARSM |
Previous Names: | serine-tRNA ligase, mitochondrial, "seryl-tRNA synthetase 2" |
Aliases: | FLJ20450, mtSerRS, SerRSmt, SARS, SERS, SYS |
Name Aliases: | serine tRNA ligase 2, mitochondrial |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1919234 | Rat Genome Database ID: | RGD:1309456 |
HGNC ID: | HGNC:17697 | RefSeq IDs: | NM_001145901 |
Entrez Gene ID: | 54938 | Ensembl Gene ID: | ENSG00000104835 |
VEGA IDs: | OTTHUMG00000071701 | UniProt ID: | Q9NP81 |
UCSC ID: | uc002oka.2 | OMIM ID: | 612804 |
Pubmed: | PMID10764807 | ||
CCDS IDs: | CCDSCCDS33017.1 |
Seryl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the SARS2 gene.
This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009].
Function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity).
Products for SARS2 gene
Catalog | Product Name | Application | Company |
GFS:E06629 | seryl-tRNA synthetase 2, mitochondrial; ELISA kit | ELISA | n/a |
GFS:A06629 | seryl-tRNA synthetase 2, mitochondrial; Anti | ANTIBODIES | n/a |
GFS:P06629 | seryl-tRNA synthetase 2, mitochondrial; Protien | Protien | n/a |