Symbol: Name: ID: |
SGK1 serum/glucocorticoid regulated kinase 1 GFS:727 |
Gene name: | SGK1 |
Chromosome: | 6q23 |
Previous Symbols: | SGK |
Previous Names: | serum/glucocorticoid regulated kinase |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1340062 | Rat Genome Database ID: | RGD:3668 |
HGNC ID: | HGNC:10810 | RefSeq IDs: | NM_001143676 |
Entrez Gene ID: | 6446 | Ensembl Gene ID: | ENSG00000118515 |
VEGA IDs: | OTTHUMG00000015613 | UniProt ID: | O00141 |
UCSC ID: | uc003qeo.3 | OMIM ID: | 602958 |
Pubmed: | PMID9114008 PMID 9722955 | ||
CCDS IDs: | CCDSCCDS5170.1 CCDS CCDS47476.1 CCDS CCDS47477.1 CCDS CCDS47478.1 |
Serine/threonine-protein kinase SGK is a kinase subfamily that is currently known as being encoded by SGK1, SGK2, and SGK3 genes. This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq].
Protein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, KCNA3/Kv1.3 or EAAT1. Isoform 2 exhibited a greater effect on cell plasma membrane expression of ENaC and Na(+) transport than isoform 1.
Products for SGK1 gene
Catalog | Product Name | Application | Company |
GFS:E00727 | serum/glucocorticoid regulated kinase 1; ELISA kit | ELISA | n/a |
GFS:A00727 | serum/glucocorticoid regulated kinase 1; Anti | ANTIBODIES | n/a |
GFS:P00727 | serum/glucocorticoid regulated kinase 1; Protien | Protien | n/a |