Symbol: Name: ID: |
SELP selectin P (granule membrane protein 140kDa, antigen CD62) GFS:640 |
Gene name: | SELP |
Chromosome: | 1q22-q25 |
Previous Symbols: | GRMP |
Previous Names: | selectin P (granule membrane protein 140kD, antigen CD62) |
Aliases: | CD62, PSEL, PADGEM, GMP140, CD62P |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98280 | Rat Genome Database ID: | RGD:3656 |
HGNC ID: | HGNC:10721 | RefSeq IDs: | NM_003005 |
Entrez Gene ID: | 6403 | Ensembl Gene ID: | ENSG00000174175 |
VEGA IDs: | OTTHUMG00000034685 | UniProt ID: | P16109 |
UCSC ID: | uc001ggi.3 | OMIM ID: | 173610 |
Pubmed: | PMID1375831 | ||
CCDS IDs: | CCDSCCDS1282.1 |
SELP encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1
Products for SELP gene
Catalog | Product Name | Application | Company |
GFS:E00640 | selectin P (granule membrane protein 140kDa, antigen CD62); ELISA kit | ELISA | n/a |
GFS:A00640 | selectin P (granule membrane protein 140kDa, antigen CD62); Anti | ANTIBODIES | n/a |
GFS:P00640 | selectin P (granule membrane protein 140kDa, antigen CD62); Protien | Protien | n/a |