Symbol: Name: ID: |
SCARB2 scavenger receptor class B, member 2 GFS:5751 |
Gene name: | SCARB2 |
Chromosome: | 4q21.1 |
Previous Symbols: | CD36L2 |
Previous Names: | CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II) |
Aliases: | HLGP85, LIMPII, SR-BII, LIMP-2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1196458 | Rat Genome Database ID: | RGD:621882 |
HGNC ID: | HGNC:1665 | RefSeq IDs: | NM_001204255 |
Entrez Gene ID: | 950 | Ensembl Gene ID: | ENSG00000138760 |
VEGA IDs: | OTTHUMG00000130099 | UniProt ID: | Q14108 |
UCSC ID: | uc003hju.1 | OMIM ID: | 602257 |
Pubmed: | PMID1374238 | ||
CCDS IDs: | CCDSCCDS3577.1 |
Lysosome membrane protein 2 is a protein that in humans is encoded by the SCARB2 gene.
The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011].
Function: May act as a lysosomal receptor.
Products for SCARB2 gene
Catalog | Product Name | Application | Company |
GFS:E05751 | scavenger receptor class B, member 2; ELISA kit | ELISA | n/a |
GFS:A05751 | scavenger receptor class B, member 2; Anti | ANTIBODIES | n/a |
GFS:P05751 | scavenger receptor class B, member 2; Protien | Protien | n/a |