Symbol: Name: ID: |
SAFB scaffold attachment factor B GFS:460 |
Gene name: | SAFB |
Chromosome: | 19p13.3-p13.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | HET, SAFB1 |
Name Aliases: | Hsp27 ERE-TATA binding protein |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2146974 | Rat Genome Database ID: | RGD:620613 |
HGNC ID: | HGNC:10520 | RefSeq IDs: | NM_001201338 |
Entrez Gene ID: | 6294 | Ensembl Gene ID: | ENSG00000160633 |
VEGA IDs: | UniProt ID: | Q15424 | |
UCSC ID: | uc002mcf.2 | OMIM ID: | 602895 |
Pubmed: | PMID9605873 PMID 8600450 | ||
CCDS IDs: | CCDSCCDS12142.1 |
SAFB encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.
Products for SAFB gene
Catalog | Product Name | Application | Company |
GFS:E00460 | scaffold attachment factor B; ELISA kit | ELISA | n/a |
GFS:A00460 | scaffold attachment factor B; Anti | ANTIBODIES | n/a |
GFS:P00460 | scaffold attachment factor B; Protien | Protien | n/a |