Symbol: Name: ID: |
SAV1 salvador homolog 1 (Drosophila) GFS:6699 |
Gene name: | SAV1 |
Chromosome: | 14q13-q23 |
Previous Symbols: | |
Previous Names: | |
Aliases: | WW45, WWP4, salvador |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1927144 | Rat Genome Database ID: | RGD:1307253 |
HGNC ID: | HGNC:17795 | RefSeq IDs: | NM_021818 |
Entrez Gene ID: | 60485 | Ensembl Gene ID: | ENSG00000151748 |
VEGA IDs: | OTTHUMG00000140293 | UniProt ID: | Q9H4B6 |
UCSC ID: | uc001wyh.1 | OMIM ID: | 607203 |
Pubmed: | PMID12202036 PMID 11027580 | ||
CCDS IDs: | CCDSCCDS9701.1 |
Protein salvador homolog 1 is a protein that in humans is encoded by the SAV1 gene.
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a coiled-coil region. It is ubiquitously expressed in adult tissues. The encoded protein is 94% identical to the mouse protein at the amino acid level. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Regulator of MST1/MST2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for MST1/MST2 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues.
Products for SAV1 gene
Catalog | Product Name | Application | Company |
GFS:E06699 | salvador homolog 1 (Drosophila); ELISA kit | ELISA | n/a |
GFS:A06699 | salvador homolog 1 (Drosophila); Anti | ANTIBODIES | n/a |
GFS:P06699 | salvador homolog 1 (Drosophila); Protien | Protien | n/a |