Symbol: Name: ID: |
RLIM ring finger protein, LIM domain interacting GFS:3015 |
Gene name: | RLIM |
Chromosome: | Xq13-q21 |
Previous Symbols: | RNF12 |
Previous Names: | ring finger protein 12 |
Aliases: | NY-REN-43, MGC15161 |
Name Aliases: | ring zinc finger protein NY-REN-43antigen, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1342291 | Rat Genome Database ID: | RGD:1559832 |
HGNC ID: | HGNC:13429 | RefSeq IDs: | NM_016120 |
Entrez Gene ID: | 51132 | Ensembl Gene ID: | ENSG00000131263 |
VEGA IDs: | OTTHUMG00000021859 | UniProt ID: | Q9NVW2 |
UCSC ID: | uc004ebw.2 | OMIM ID: | 300379 |
Pubmed: | PMID10508479 | ||
CCDS IDs: | CCDSCCDS14427.1 |
E3 ubiquitin-protein ligase RLIM is an enzyme that in humans is encoded by the RLIM gene.
The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be an E3 ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq].
Function: E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. Acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.
Products for RLIM gene
Catalog | Product Name | Application | Company |
GFS:E03015 | ring finger protein, LIM domain interacting; ELISA kit | ELISA | n/a |
GFS:A03015 | ring finger protein, LIM domain interacting; Anti | ANTIBODIES | n/a |
GFS:P03015 | ring finger protein, LIM domain interacting; Protien | Protien | n/a |